Published June 10, 2022
| Version v1
Journal article
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UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATIONOF TERIFLUNOMIDEIN TABLET
- 1. Teriflunomide is the active metabolite of leflunomide. It is an immunomodulatory agent used in the treatment of multiple sclerosis. UV spectrophotometric method has been developed for the estimation of teriflunomide in tablets using methanol as solvent. Teriflunomide has shown λmaxat293nm.The method hasbeen validated according to ICH Q2 (R1) guidelines. Alinear responseis observed(R2=0.9995) in therange of 4-20μg/ml, with recovery (100.68%) andprecision (% RSD is 0.07).This method is simpleand suitable for routine pharmaceutical analysis.
Description
Teriflunomide is the active metabolite of leflunomide. It is an immunomodulatory agent used in the treatment of multiple sclerosis. UV spectrophotometric method has been developed for the estimation of teriflunomide in tablets using methanol as solvent. Teriflunomide has shown λmaxat293nm.The method hasbeen validated according to ICH Q2 (R1) guidelines. Alinear responseis observed(R2=0.9995) in therange of 4-20μg/ml, with recovery (100.68%) andprecision (% RSD is 0.07).This method is simpleand suitable for routine pharmaceutical analysis.
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