Results of treatment of cancer patients with peritoneal carcinomatosis

Bondar O. V., Rybin A. I., Varabina A. O. Results of treatment of cancer patients with peritoneal carcinomatosis. Journal of Education, Health and Sport. 2022;12(5):304-314. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.05.024

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.05.024

https://zenodo.org/record/6616754

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

 © The Authors 2022;

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Received: 29.04.2022. Revised: 11.05.2022. Accepted: 31.05.2022.

Results of treatment of cancer patients with peritoneal carcinomatosis

O. V. Bondar, A. I. Rybin, A. O. Varabina

Odessa National Medical University

Abstract

Objective: At present, common forms of cancer of different localization can not be ignored. New approaches to the treatment of metastatic lesions have some success in clinical application. This study is devoted to the experience of using the technology of cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in practice, as well as the analysis of overall and relapse-free survival in the examined groups of patients.

Patients and methods: A total of 119 people were recruited from 2013 to 2020 inclusive. Patients were divided into two groups: the clinical control group (n = 53) consisted of individuals who underwent suboptimal cytoreduction; in the main group (n = 66) there were patients who performed optimal or complete cytoreductive volume and in some cases underwent intraoperative hyperthermic chemotherapy. Patients diagnosed with stage IIIC ovarian cancer were treated. In the initial analysis of these groups, time indicators (period before surgery, duration of surgery, number of postoperative bed-days), as well as the presence and nature of complications in the postoperative period were taken into account.

Results: The analysis showed an increase in relapse-free survival from 10 months in the control group to 13-19 months in the main group, also significantly increased (from 5 to 22%) the number of complications of class III-IV in HIPEC.

Conclusion: The study is prospective and retrospective, recruitment into groups has been conducted since 2013. Observation of the studied groups continues. The expected results will be a significant discrepancy between overall and recurrence-free survival in the study groups.

Key words: ovarian cancer; carcinomatosis; treatment; HIPEC; cytoreduction.