DoxAv1: SCR, ECG, respiration, startle eyeblink EMG and eyetracking measurements in an RCT using doxycycline/placebo during trace fear conditioning and retention.

This dataset contains skin conductance responses (SCR), electrocardyogram (ECG), respiration, electromygram (EMG), pupil size (PSR), and gaze coordinates measurements for 97 healthy subjects (49 females and 48 males aged 24.7 +/- 3.9) participating in a double-blind, placebo-controlled, randomized trial using a Pavlovian differential trace fear conditioning experiment with 2 sessions. The placebo group (n = 48) includes 24 females and 24 males, aged 24.09 +/- 4.06 years; the doxycycline (n = 49) group includes 25 females and 24 males, aged 24.43 +/- 3.75 years.
CSs were isoluminant colored triangles presented on the screen center with grey background. US was a train of 83 square electric pulses with 0.2 ms duration with a duty cycle of 1.67%, delivered with a constant current stimulator on participants' dominant forearm through a pin-cathod/ring-anode configuration. SOA between the CS onset and US was 17 s. Participants underwent the conditioning task with CSs (CS+ 100% reinforced) and US delivery in session 1 with 4 blocks, and were tested in a retention/extinction task one week later in session 2 with 3 blocks, with CS and auditory startle probe (ST) delivered 15 s after CS onset via headphones (ca. 102 dB, 50 ms duration). No US was delivered during session 2. Participants in the doxycycline group received a single oral dosage of doxycycline à 200mg ~210 min before the start of fear conditioning in session 1, while the placebo group received a placebo (manitol). The ITI was jittered on each trial to be 30 +/- 2 s. During ITI, an attention task was performed with 14 sub-trials. The blocks in each session were recorded on the same day with self-paced breaks.