Published April 23, 2022 | Version 4.0.6 (Merlion)
Software Open

SimThyr

Authors/Creators

  • 1. Bergmannsheil University Hospitals, Ruhr University of Bochum

Contributors

Project manager:

Related person:

  • 1. Ruhr University Bochum
  • 2. Klinikum Luedenscheid
  • 3. North Lakes Clinical
  • 4. Ludwig-Maximilian-University of Munich

Description

SimThyr is a numeric simulator of pituitary-thyroid feedback control (aka thyrotropic feedback control, hypothalamus-pituitary-thyroid axis or thyroid homeostasis), based on a non-linear MiMe-NoCoDI model of the information processing structure. Its intended main use is in education and in silico research.

Files

Kubota_et_al._2010_v1.2.zip

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Additional details

Identifiers

URL
http://scicrunch.org/browse/resources/SCR_014351

Is cited by
Journal article: 23365787 (PMID)
Journal article: PMC3544290 (pmcid)
Journal article: 10.1136/jclinpath-2012-201213 (DOI)
Journal article: 23423518 (PMID)
Journal article: 10.1530/EJE-12-0819 (DOI)
Journal article: 23184912 (PMID)
Journal article: 25750078 (PMID)
Journal article: 10.1055/s-0034-1398616 (DOI)
Journal article: 27375554 (PMID)
Journal article: PMC4899439 (pmcid)
Journal article: 10.3389/fendo.2016.00057 (DOI)
Journal article: 28775711 (PMID)
Journal article: PMC5517413 (pmcid)
Journal article: 10.3389/fendo.2017.00163 (DOI)
Journal article: 29155897 (ean8)
Journal article: PMC5695809 (pmcid)
Journal article: 10.1371/journal.pone.0187232 (DOI)
Journal article: 30022470 (PMID)
Journal article: 10.1111/eci.13003 (DOI)
Is part of
Journal article: http://simthyr.sourceforge.net (URL)
Is supplement to
Book: 978-3-89722-850-4 (ISBN)
Journal article: 10.1155/2012/351864 (DOI)
Is supplemented by
Software: https://github.com/jwdietrich21/simthyr (URL)

References

  • J. W. DIETRICH, A. TESCHE, C. R. PICKARDT & U. MITZDORF (2004) THYROTROPIC FEEDBACK CONTROL: EVIDENCE FOR AN ADDITIONAL ULTRASHORT FEEDBACK LOOP FROM FRACTAL ANALYSIS, Cybernetics and Systems, 35:4, 315-331, DOI: 10.1080/01969720490443354
  • Johannes W. Dietrich, Gabi Landgrafe, and Elisavet H. Fotiadou, "TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis," Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. https://doi.org/10.1155/2012/351864.
  • Midgley JEM, Hoermann R, Larisch R, Dietrich JW. Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 2013;66:335-342.
  • Hoermann R, Midgley JE, Larisch R, Dietrich JW. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur J Endocrinol. 2013 Jan 17;168(2):271-80. doi: 10.1530/EJE-12-0819. PMID 23184912.
  • Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Horm Metab Res. 2015 Aug;47(9):674-80. doi: 10.1055/s-0034-1398616. PMID 25750078.
  • Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, Hoermann R. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.
  • Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW. Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Front Endocrinol (Lausanne). 2017 Jul 20;8:163. doi: 10.3389/fendo.2017.00163. PMID: 28775711; PMCID: PMC5517413.
  • Hoermann R, Midgley JEM, Larisch R, Dietrich JWC. Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine. PLoS One. 2017 Nov 20;12(11):e0187232. doi: 10.1371/journal.pone.0187232. PMID: 29155897; PMCID: PMC5695809.

Subjects

Homo sapiens
http://www.eol.org/pages/327955/
Hypothalamus
https://www.ncbi.nlm.nih.gov/mesh/68007031
Pituitary Gland
https://www.ncbi.nlm.nih.gov/mesh/68010902
Thyroid Gland
https://www.ncbi.nlm.nih.gov/mesh/68013961
Thyrotropin
https://www.ncbi.nlm.nih.gov/mesh/68013972
Thyroid Hormones
https://www.ncbi.nlm.nih.gov/mesh/68013963
Homeostasis
https://www.ncbi.nlm.nih.gov/mesh/68006706