Published November 22, 2022 | Version 0
Dataset Open

Gut metabolites predict Clostridioides difficile recurrence

Authors/Creators

  • 1. Brighham & Woman's Hospital; Harvard-MIT Health Sciences & Technology
  • 2. Massachusetts Host-Microbiome Center; Brigham & Woman's Hospital
  • 3. Brigham & Woman's Hospital, Harvard Medical School
  • 4. Massachusetts Host-Microbiome Center
  • 5. Brigham & Woman's Hospital; Massachusetts Host-Microbiome Center
  • 6. Brigham & Woman's Hospital; Massachusetts Host-Microbiome Center; Harvard-MIT Health Sciences and Technology

Description

This repository contains:

1. Data used for analyses from:

A) 16S rRNA gene amplicon analysis after paired-end Fastq files were truncated, filtered, denoised, and merged ["1-ASV_Counts.xlsx"]

B) Untargeted metabolomics as provided by Metabolon ["2-UntargetedMetabolomics.xlsx"]

C) Precision SCFA analysis ["3-PrecisionSCFA.xlsx"]

D) Clincal demographic data of the study cohort ["Clinical Demographics.csv"]

 

2. Detailed results of univariate analyses in sub-folder "Univariate analysis results" for clinical data, untargeted metabolomics data, SCFAs, and ASVs

 

3. Detailed results of predictive analysis in subfolder "Predictive Analyses results", including per-fold performance results ("9-PredictiveResults.xlsx") and analysis of predictive features for ASVs ("10-ASVsPredictiveAnalysis.xlsx"), untargeted metabolites ("11-MetabsPredictiveAnalysis.xlsx"), targeted SCFAs ("12-SCFAPredictive Analysis.xlsx"), clinical data ("13-DemoPredictiveAnalysis.xlsx") and all data ("14-AllDataPredictiveAnalysis.xlsx")

4. Data for generating all figures and analyses in the publication ("GenFigure&AnalysesData")

Files

Data.zip

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