C-reactive protein to albumin ratio, albumin to globulin ratio and platelet to lymphocyte ratio in patients with spondyloarthritis

Aim: The C-reactive protein (CRP) to albumin ratio (CAR) has been reported as a novel inflammatory marker to assess inflammation. Serum globulin increases in inflammation. In this study, it was aimed to evaluate relation between CAR, albumin to globülin ratio (AGR), platelet to lymphocyte ratio (PLR) and disease activity in patients with axial spondyloarthritis (AxSpA). Method: Seventy-five patients with axial SpA and seventy-five healthy controls were evaluated retrospectively. CRP, albumin, globulin, leukocyte, lymphocyte, and platelet from the patients and controls were recorded. CAR, AGR and PLR were calculated. Disease activity was evaluated by the BASDAI and ASDAS. Results: The mean age was 38.2±10.39 years in patients with AxSpA and 35.45±8.96 years in controls. The CAR was 0.153±0.2 in AxSpA patients and 0.03±0.02 in controls (p<0.05). The CAR was 0.0972±0.16 in patients who had low disease activity and 0.213±0.275 in patients with high disease activity. The patients with high disease activity had higher CAR than patients with low disease activity (p<0.05). There was a statistically significant positive correlation between CAR and BASDAI and ASDAS respectively (rho 327, p<0.05, rho 0.523, p<0.05). The AGR was lower in AxSpA patients (p<0.05). There was a negative correlation between AGR and BASDAI but it was not significant (rho – 0.044, p>0.05). There was significant correlation between PLR and BASDAI and ASDAS (rho 236, p<0.05 and rho 314, p<0.05 respectively). Conclusion: The CAR and PLR are an important markers for evaluating disease activity in patients with AxSpA. AGR may be a promising marker for assessing disease activity in AxSpA.