Published April 10, 2022 | Version v1
Journal article Open

A Facile Three-Steps, One-Pot Synthesis of Novel 2-Alkylamino and 2-Dialkylamino-4H-Pyrido [1, 2-A][1,3,5] Triazin-4-Ones from  2-Aminopyridine and 2-Aminopicolines

Authors/Creators

  • 1. University Hassan first. Settat, Morocco. Laboratory of Environmental and Development Sciences. Ecological chemistry team, Faculty of Science and Technology. & Normandy Center for Studies and Research on Medicines, Faculty of Pharmaceutical Sciences, University of Caen. 5, rue Vaubénard, 14032 Caen Cedex, France.
  • 2. University Hassan first. Settat, Morocco. Applied Chemistry and Environment Laboratory, Faculty of Science and Technology. & University Hassan first.. Settat, Morocco. Health Sciences and Technology Laboratory, higher institute of health sciences.
  • 3. University Hassan first. Settat, Morocco. physico-chemistry of processes and materials Laboratory, Faculty of Science and Technology.
  • 4. Normandy Center for Studies and Research on Medicines, Faculty of Pharmaceutical Sciences, University of Caen. 5, rue Vaubénard, 14032 Caen Cedex, France.
  • 5. University Hassan first. Settat, Morocco. Applied Chemistry and Environment Laboratory, Faculty of Science and Technology.
  • 6. University Hassan first. Settat, Morocco. Matter and Instrumentation Radiation Laboratory, Faculty of Science and Technology

Description

Abstract :

A straightforward approach to novel 2-dialkylamino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones synthesis is presented. The construction of these compounds was achieved by one-pot synthesis involving condensation of 2-aminopyridine or 2-aminopicolines with ethoxycarbonylisothiocianate, followed by amination of the thioureas, and finally thermal ring closure of resulting guanidines. This allowed access to the unreported title heterocycles. We described an efficient, facile, one-pot synthesis of a novel 2-dialkylamino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones in order to obtain a library of pyridotriazines which will be used as building blocks in medicinal chemistry.

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