Amino Acid Esters of Norethindrone as Possible Acrosin Inhibitors

Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226 001

Manuscript received 10 October 1985, accepted 17 February 1986

A series of amino acid esters of norethindrone (I) have been synthesised as possible acrosin inhibitors by reacting different amino acids with I in the presence of equimolar amounts of 4-N,N-diaethylaminopyridine (DMAP) and dicyclohexylcarbodiimide (DCC).