Synthesis of 1-Aryl-2-mercapto-4-phenyl-1 ,6-dihydro-1,3,5-triazine-6-thiones and their Addition Products with α,β-Unsaturated Carbonyl Compounds and Aryl Cyanamides as Antithyroidal Agen

Department of Chemistry, Banaras _Hindu University, Varanasi-221 005

Manuscript received 11 September 1991, revised 25 June 1992, accepted 3 July 1992                                       

Different 1-aryl-2-mercapto-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thiones have been synthesised by the dealkylatien of 1-aryi­2-benzylmercapto-4-phenyl-1, 6-dihydro-1, 3, 5-triazine-6-thione with thiourea and HCl. These mercapto triazine when treated with \(\propto\),β- unsaturated carbonyl compounds and aryl cyanamides gave the corresponding addition products and tested for their antithyroidal activity.