Bridgehead Nitrogen Heterocyclic Systems. Synthesis and Antimicrobial Activity of s-Triazolo[3,4-b ][ 1,3,4]thiadiazines, Thiazolo[3,2-b ]-s-triazoles and Isomeric Thiazolor2,3-c]-s-triazoles

Department of Chemistry, Maharshi Dayanand University, Robtak-124 001

Manuscript received 27 November 1991, revised 24 March 1992, accepted 1 April 1992

The isomeric triazoles (6 and 8) both fused with the 2,3-bond of a thiazole, have been prepared starting from the thiosemi­carbazide (2). The triazolo[3,4-b] [1,3,4] thiadiazine (9 ; R⁶=C₆H₅ and C₆H₅CI-p) arises from the condensation of the triazole (5) with haloketone (R⁶=COCH₂Br). The antibacterial and antifungal activity of the above products have been evaluated.