Published November 16, 2020 | Version v1
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Polymeric 19F MRI Contrast Agents Prepared by Ring-Opening Metathesis Polymerization/Dihydroxylation

  • 1. University of Fribourg
  • 2. Andreas F.M.


The capability of ring-opening metathesis polymerization (ROMP) to efficiently incorporate bulky monomers and conserve olefin bonds during polymerization was exploited to design water-soluble fluoropolymers, which were evaluated as potential quantitative 19F magnetic resonance imaging (MRI) contrast agents. The fluoromonomeric units comprised 3, 6, 9, or 18 magnetically equivalent fluorine atoms. Aqueous solubility was achieved through dihydroxylation of the partially unsaturated polymeric backbone and by tetraethylene glycol (TEG)-based linker incorporation, ammonium quaternization, or copolymerization.



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