Synthesis and antibacterial activities of 1-(p-chloropheny1)- 2-amino/hydrazino-4-nitrophenyl/p-chloropheny1)-1,6-dihydro ¬1,3,5-triazine-6-thiones and related thiocarbamides, thiosemicar- bazides and Schiff bases

Department of Chemistry, Banaras Hindu University, Varanasi-221 005, India

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Manuscript received 27 November 2000, revised 19 March 2001. accepted 5 June 2001

1-(p-ChlorophenyI)-2-benzylmercapto-4-0-nitrophenyl/p-chloropheny1)-1,6-dihydro-1,3,5-trazine-6-thiones (1) on treatment with am­monia/hydrazine hydrate under suitable conditions afford the corresponding 2-amino/hydrazino derivatives (2, 3). The latter on treatment with aryl isothiocyanates/aryl aldehydes afford the related thiocarbamides/thiosemicarbazides/Schiff bases (4.6) which have been tested for their antibacterial activity.