Selective bromination of acetophenone derivatives with bromine in methanol

E-mail: amritgoswami@yahoo.com                Fax : 91-0376-370011

Manuscript received 18 August 2000, revised 3 August 2001, accepted 19 October 2001

Acetophenone derivatives are selectively brominated in the acetyl side-chain with bromine in methanol at 0-5° by manipu­lating the electron density in the aromatic ring in good yield.