Figure 3 from: Ayyar P, Subramanian U (2022) Repurposing – second life for drugs. Pharmacia 69(1): 51-59. https://doi.org/10.3897/pharmacia.69.e72548

Figure 3 A) Swanson's ABC model B) Signature similarity approach – Drug B has inverse signature similarity with the disease against which it is effective and drug A with similar signature to drug B can be potentially repurposed for the same disease C) Side effect similarity approach D) Associative indication transfer approach.