Synthesis and biological activity of some benzofuro[3,2-d]pyrimidines

Department of Studies and Research in Chemistry. Gulbarga University, Gulbarga-585 106, India

E-mail : bodke___yd@rediffmail.com

Manuscript received 21 December 2001 .revised 18 April 2002, accepted 12 December 2002

The condensation of ethyl 3-amino-2-benzofuran carboxylate (1) with phenyl isocyanate gave 3-phenylureido-2-benzofuran carboxylate (2), which upon treatment with phosphorus oxychloride gave 2-chloro-3-phenyl-3,4-dihydro-4-oxohenzofnro[3,2-d]pyrimidine (4). The reaction of 4 with alicyclic amines like piperidine and morpholine yielded 2-piperidino/morpholino compounds (5a and 5b, respectively). 2-Hydrazino-3-phenyl-3,4-dihydro-4-oxobenzofuro[3,-d]pyrimidine 16) obtained from 4 was subjected to reactions with different reagents. All compounds were screened for their antibacterial and antifungal activities.