Synthesis and tiiological activity of some N-aryl-4-(5-methyl-[1,3,4]-oxadiazolin- 2-one-3-yl) substituted benzamides from 3-(4-carboxy)phenylsydnone

P. G. Department of Chemistry, Karnatak University, Dharwad-580 003, Karnataka. India

E-mail : bbadami@rediffmail.com

Manuscript received 11 April 2005, revised 8 May 2006, accepted 31 July 2006

The title compounds N-aryl-4-(5-methyl-[1,3,4]-oxadiazolin-2-one-3-yl) substituted benzamides (5a-h) were synthesized from 3-(4-carboxy)phenylsydnone (1) by using one-pot ring conversion reaction of sydnone to 1,3,4-oxadiazolin- 2-one. Preliminary antimicrobial screening of these compounds exhibited higher activity for some of them as compared to the reference drugs used.