Synthesis and evaluation of insect repellent activity of 4-amino-5-(4-bromobenzoyl)- 3-ethyl-2(1H)-pyrimidone, on Setophilus oryzαe (Coleo curculeonidαe)

Postgraduate Department of Chemistry, K. T. H. M. College, Nashik-422 002, Maharashtra. India

E-mail : toche_raghunath@yahoo.com.in

Department of Chemistry, Arts, Science and Commerce College, CIDCO, Nashik, Maharashtra, India

Department of Zoology, K. T. H. M. College, Nashik-422 002, Maharashtra, India

Manuscript received 13 April 2004, revised 10 May 2006, accepted 28 June 2006

One pot synthesis of 2-(4-bromobenzoyl)-3-ethylureidopropenenitrile (4) was obtained by heating 4-bromobenzoyl acetomtrlle (1), ethylurea (2) and triethylorthoformate (3) Compound 4 was cyclized to target molecule 4-amino-5-(4- bromobenzoyl)-3-ethyl-2(1H)-pyrimldone (5) by sodiumethoxide. The insect repellent activity of 4 and 5 was evaluated on \(Setophilus\) \(oryzac\) (\(Coleo\) \(curculeonidae\)) at various concentrations.