Aminomethylation reactions of nitrogen and sulfur five membered heterocyclic compounds

Department of Chemistry, University of Lucknow, Lucknow-226 007, India
E-mail : profraj @sancharnet.in

Five membered nitrogen and sulfur heterocyclic compounds such as isatins, benzimidazole, benzimidazolin-2-thione, benzoxazoli none- 2, benzoxazoline-2-thione, benzotriazole, benzothiazoline-2 -thione, 1 ,3,4-oxadiazoline-5-thione and 1,2,4-triazolin-5-thiones have been prepared and subjected to aminomethylation reactions in presence of formaldehyde and amines. Secondary as well as primary aromatic amines bearing different substituents have been successfully utilized in the aminomethylation reaction. The aminomethylated products have been tested for antibacterial, antifungal, antiviral, anticancer, antileishmanial and antifilarial activity. A number of such products have exhibited promising antifungal and antileishmanial activities.