Heterocyclization of some chalcones to isoxazoles, pyrazoles and pyrimidine nuclei under microwave irradiation and their biological profile

Microwave Synthetic Laboratory, Department of Chemistry, College of Science, M. L. Sukhadia University,
Udaipur-313 001, Rajasthan, India
E-mail : rituvyas_23@yahoo.co.in
PI Industries Ltd., Udaisagar Road, Udaipur-313 001, Rajasthan, India
Manuscript received 2 September 2008, accepted 1 October 2008

Rapid and efficient methods for the preparation of a set of isoxazole, pyrazole and pyrimidine derivatives of
imidazolinone and quinazolinone by the reaction of 5-substituted arylidene-{2-(imidazolyl/quinazolyl)imino }thiazolidinone
(chalcones) with hydroxylamine, urea and hydrazine hydrate under MWI are reported. Excellent yields and higher purity
are obtained in MW enhanced synthesis as compared to the conventional procedure which required exceedingly long
reaction times, high temperatures and tedious workups. The potent antimicrobial effects of the synthesized compounds
were investigated.