Synthesis and antimicrobial activities of novel tetrahydroquinoline and tetrahydroisoquinoline analogues

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835 215,

Jharkhand, India

E-mail: pompil23@rediffmail.com

Manuscript received 11 May 2009, revised 14 December 2009, accepted 14 January 2010

A series of tetrahydroquinoline and tetrahydroisoquinoline derivatives were synthesized and their structures were confirmed by spectral (FT-IR, NMR and Mass) data analysis. These analogs were evaluated for their in vitro antibacterial activity against Staplaylococcus aureus, Bacillus subtilis, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Mycobacterium tuberculosis (H₃₇Rv strain) and antifungal activity against Candida albicans and Aspergillus niger.