Substituted [1,2,4,5]-dithiadiazines and [1,3,4]-thiadiazolidines; synthesis, characterization and antimicrobial study

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 00I,

Maharashtra, India

E-mail : pradip22209l@yahoo.co.in

Manuscript received 12 August 2009, revised 29 February 2012, accepted 14 March 2012

Series of compounds 2-benzotriazol-1-yl-1-(3-phenylimino-6-aryl/alkylimino-[1,2,4,5]-dithiadiazinan-4-yl)-ethanones and 2-benzotriazol-1-yl-l-(2-phenylimino-5-aryl/alkylimino-[1,3,4]·thiadiazolidin-3-yl)-ethanones have been synthesited by the interaction of 2-benzotriazol-1-yi-N-aryl/alkyl thiocarbamido-acetamides with N-phenyi-S-chloro isothiocarbamoyl chloride and N-phenyl isocyanodichloride respectively. These compounds on acetylation afforded acetyl derivatives. The title compounds have been assayed for their antimicrobial activity against Gram-positive as well as Gram-negative microorganisms.