Efficient synthesis of pharmaceutically important fluorinated benzo[b]furans

Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India

Department of Chemistry, JECRC UDML College of Engineering, Jaipur-302 028, Rajasthan, India

E-mail : at.chem@gmail.com

Manuscript received online 28 January 2013, revised 08 February 2013, accepted 06 April 2013

Fluorination of 2-aroylbenzo[b]furans has been successfully accomplished by diethylaminosulfur trifluoride (DAST). Transformation of carbonyl group occurs into difluoromethylene group. All the synthesized compounds have been characterized by elemental analysis and spectral data (IR, ¹H NMR, ¹⁹F NMR and FAB mass). All the synthesized title compounds have also been evaluated for their antibacterial and antifungal activities against S. aureus, E. coli and A. flavus and A. niger. All the compounds have shown promising results which supports the use of these compounds as a potent antimicrobial agent.