The convenient microwave-assisted synthesis, characterization and structural study of substituted bis-[1,2,4]-dithiazolidines

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001,

Maharashtra, India

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440 033,

Maharashtra, India

E-mail : pradip222091@yahoo.co.in

Manuscript received online 05 December 2012, revised 21 February 2014, accepted 28 February 2014

A convenient synthesis of substituted bis-[1,2,4]-dithiazolidines has been developed by using the environmentfriendly technique of microwave irradiation. The microwave-assisted synthesis of several members of the titled class has been achieved by the interaction of 1-{4-[4-(3-aryl thiocarbamido)-3-nitro/carboxy-benzyl]-2-nitro/carboxy-phenyl}- 3-aryl thiocarbamides with N-phenyl-S-chloro isothiocarbamoyl chloride under solvent-free condition, followed by basification with dilute ammonium hydroxide solution. Initially, 1-{4-[4-(3-aryl thiocarbamido)-3-nitro/carboxy-benzyl]- 2-nitro/carboxy-phenyl}-3-aryl thiocarbamides were prepared by irradiating the mixtures of different aryl isothiocyanates with 4,4´-methylene-bis-(2-nitro-aniline)/(anthranilic acid) under microwave for specified time. The constitutions of synthesized compounds have been delineated on the basis of chemical transformation, elemental analysis, equivalent weight determination, IR and ¹H NMR spectral studies.