Published September 1, 2020 | Version v1
Journal article Open

Synthesis, characterization and antimicrobial evaluation of some new substituted 1H-indole-2 carboxamide derivatives


Department of Chemistry, The University of Jordan, Amman, 11942, Jordan

Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, Jordan

Department of Chemical Science and Engineering, School of Engineering, Kathmandu University, Nepal


Manuscript received online 19 July 2020, accepted 28 August 2020

A new series of 1H-indole-2-carboxamide derivatives has been prepared by simple procedures in good yields, followed by complete characterization using nuclear magnetic resonance, infrared spectroscopy, high resolution mass spectrometry and elemental analysis techniques. The prepared compounds have been tested as potential antifungal and anti-bacterial (Grampositive and Gram-negative) agents. The antifungal and antibacterial results indicated that carboxylic acid compounds exhibited a weak bioactivity; even with replacement of carboxylic acid group with ester, no significant difference in activities was observed relative to standard commercial drugs.


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