Bismuth nitrate-induced microwave-mediated deglycosylation of O-glycosides: Synthesis of enantiopure 3-hydroxy β-lactams

Department of Molecular Pathology, The University of Texas-M. D. Anderson Cancer Centre, 1515 Holcombe Blvd.,

Houston, Texas 77030, USA

Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg,

Texas 78539, USA

Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Castle Point on the Hudson,

Hoboken, New Jersey 07030, USA

Current Address: Vice President of Research and Education Development, Community Health Systems of South

Texas, 3135 South Sugar Road, Edinburg, Texas 78539, USA

E-mail: bimalbanik10@gmail.com, bimal.banik@chsst.org

Manuscript received 01 October 2018, accepted 02 November 2018

Bismuth nitrate-induced microwave-mediated cleavages of O-glycosidic bond in β-lactams are achieved to afford their corresponding hydroxyl derivatives in excellent yields.