Cell Reprogramming Technology Advances and Exploration of Human Teeth Renewal Capacity

Having a third dentition is a major goal of dental regenerative medicine. However, the development of new teeth does indeed require dental epithelium, which can permit genesis of organized temporal rhythms necessary for spatial form events. Nonetheless, the current advances in cell fate engineering both in vitro and in vivo are now quite numerous, enriching the research and promising us to begin to explore how dental regenerative medicine can be of valuable benefit. Our threefold aim is to first update research of the literature, then explore new theories and eventually experiment with the developmental origin of relationships between oral mucosa and dental tissues. In part two of our research, we will start by analyzing the feasibility of in situ recruitment and conversion of oral mucosa to odontogenic tissues and then proceed to reviewing the multifunctional microsystems and/or nanosystems as innovative dental devices that can permit local in vivo direct cell reprogramming of oral mucosa to acquire odontogenic properties, which will allow us to assess the orchestrating reactivation of odontogenesis events for an episodic whole tooth renewal. A final aim of this review is to explore recent advances in ideas and progress towards the approach of possible and feasible use of in situ reactivation of human odontogenesis processes like that of early development, which can be achieved safely, and efficiently and be applied to clinical practice. This approach is supported by the inductive capacity of the oral mucosa for building up functional dental cells and tissue like that of early dental development. Adopting a scrupulous evaluation of the challenges and limits of this approach, this work aspires to underline the imperative that the in vivo genesis of germs with all odontogenesis steps could dictate a third dentition wherever possible.