Eco-friendly synthesis of amides and their microbial activity

Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, Punjab, India

E-mail : taniabansal2@yahoo.com, jyotgcw@gmail.com

Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, Punjab, India

E-mail : sunita_sharma@pau.edu

Manuscript received online 23 July 2014, accepted 18 August 2014

A series of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenoxy-3-phenylacrylamide 5a-e, 1-morpholino-2-phenoxy-3-phenyl prop-2-ene-1-one 7a-e and 2-phenoxy-3-phenyl-N-(4H-1,2,4-triazole-4-yl)acrylamide 9a-e were synthesized, characterized and screened for their microbial activities. All these compounds were prepared by conventional and microwave assisted methods from corresponding acrylic acids and amines. All amide derivatives prepared by microwave irradiation method gave higher yield and took less time. Amide derivatives were screened for their microbial activity against different bacteria viz. Ensifer sp. (LSR 3), Pseudomonas sp. (PGPR 3), Staphylococcus aureus and Escherichia coli. The results of antibacterial screening revealed that some of the synthesized amide derivatives exhibited poor inhibition against Ensifer sp., Pseudomonas sp., S. aureus and E. coli while remaining compounds displayed mild to moderate antibacterial activity. Maximum degree of inhibition (zone 20 mm) was shown by the compounds containing triazole moiety against E. coli.