Presentation of a case with Amyloidosis to various organs

Amyloidosis is a heterogeneous group of diseases, in which one or more organs are infiltrated by extracellular proteinaceous deposits, known as amyloid. These deposits aggregates in the form of insoluble fibrils. The prognosis of the disease is determined both by the organ(s) involved and the type of the amyloid. Except of the brain other organs can be affected too: kidney, liver, spleen, lung, gastrointestinal tract, endocrine organs, skin and heart. In its early stages, amyloidosis might not cause symptoms. When it becomes more severe, which symptoms you have depend on the organ or organs that are affected. Amyloidosis is divided into systemic and localized or acquired and hereditary. The 4 main types of systemic amyloidosis are: a) primary or Amyloid Light-chain (AL) amyloidosis, b) secondary or disorder of A chains amyloidosis (AA, which frequently appears in combination with inflammatory diseases), c) Amyloid Transthyretin (ATTR) amyloidosis and d) Amyloid Beta 2-microglobulin (Aβ2M) amyloidosis, associated with dialysis.