Published September 16, 2021 | Version V2 31-8-2021
Journal article Open

Protocol effectiveness of COVID-19 vaccines on variant of concern. A systematic review of observational studies

  • 1. Université de Paris, Inserm, Cochrane France, AP-HP, France


This is a protocol of a living systematic review of vaccine observational studies. Our aim is to assess the effectiveness of COVID-19 vaccines against SARS CoV-2 variants of concern Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) in addition to any other newly discovered variants of concerns as identified by WHO over time.. All results will be made available on the COVID-NMA platform ( and updated weekly.


covid_nma_os_vaccines_protocol_2021-09-01 (1).pdf

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