The Hour of Awakening and SARS-Cov-2 Risk: is there a melatonin effect?

The Best Choice: Sleeping Between 19 to 3 (or 4).

Based on Data of 6000 Iranian Families.

Most melatonin secretion occurs between 2 and 4 am in people who are asleep (during rapid irregular eye movements during sleep). Therefore, waking up during these hours reduces melatonin secretion. Decreased melatonin secretion increases insulin secretion during these hours. Therefore, waking up at 2 to 4 o'clock can help treat metabolic syndrome or similar conditions. Perhaps the reason for the minimal risk of SARS-Cov-2 apparent Infection in people who wake up at 4 am lies in the relationship between melatonin and insulin on the one hand, and the relationship between insulin and SARS-Cov-2 risks on the other.

Another possibility can be raised: During deep sleep, especially around 3 to 4 a.m., as well as during the REM phase of sleep, cytokines and free ATPs are released. This event may exacerbate the cytokine storm and worsen the SARS-COV-2 condition and symptoms. There is statistical evidence from Google Trends that the deteriorating condition of COVID-19 patients, in different countries involved in the pandemic, is experiencing a worsening of the condition every day between 3 and 7 a.m.

this evidence suggests that deep sleep, especially between 3 and 7 a.m., can exacerbate SARS-COV-2 disease. Therefore, it should be considered that through the management of patients' sleep hours, it may be possible to better control treatment outcomes to reduce mortality. Also, more research should be done to investigate the effect of patients' sleep time and sleep patterns on the SARS-COV-2 biological processes.