Published September 10, 2021 | Version v1
Poster Open

The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation

Description

The localised surface plasmon resonance (LSPR) peak of gold nanorods (GNRs) is located in the near-infrared optical window and is sensitive to local binding events, enabling label-free detection of biomarkers in complex biological fluids. Glycan-binding proteins, called lectins, play a key role in many biological processes.
To enable LSPR-based biosensing, the nanoparticles must be decorated with recognition units tethered to the surface by a ligand. We studied the sensing performance of GNRs coated with galactosamine-modified polymeric linkers for the detection of the lectin soybean agglutinin (SBA), used as a model analyte.
 

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Funding

NanoCarb – Glyco-Nanoparticles for Applications in Advance Nanomedicine 814236
European Commission