Published September 1, 2021
| Version v1
Journal article
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Limit of detection (LOD) in nonlinear concentration-response curves, with application in in-vitro mutagenicity assays
Authors/Creators
- 1. Leibniz University Hannover (retired)
- 2. Xenometrix AG, CH-4123 Allschwil
- 3. Societe des Produits Nestle, CH-1000 Lausanne 26
- 4. National Institute of Public Health (Statens Institut for Folkesundhed), DK-1455 Kobenhavn
Description
Different-shaped nonlinear concentration-response curves of various in-vitro assays can be compared by their limit of detection (LOD).
To estimate an effective dose (as LOD), a nonlinear model fit and the intercept of its prediction limit with concentration 0 is used.
This represents an extension of the common calibration curve LOD estimation for strict linear concentration-response curves, conditionally after suitable transformation.
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LOD082021.pdf
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