Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model
Authors/Creators
- 1. Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark, Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany
- 2. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 3. Department of Exploratory Toxicology, H. Lundbeck A/S, Valby, Denmark
- 4. Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
- 5. Department of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany
- 6. Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Description
Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of
death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI
reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an
amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of
reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment
prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats.
No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential
drug candidate to prevent VF in the first minutes to hours of AMI.
Notes
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