Published March 26, 2020 | Version v1
Dataset Open

Respiratory virus shedding in exhaled breath and efficacy of face masks

Description

We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in the exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols, with a marginally significant reduction in coronavirus RNA in respiratory droplets. Our results indicate that surgical facemasks could prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals.

Notes

Attached 10 files to generate all figures (except Extended Data Figure 1) and tables in:
Leung NHL, Chu DKW, Shiu EYC et al. Respiratory Virus Shedding in Exhaled Breath and Efficacy of Face Masks. Nat Med 2020.

The 10 files include:
1) Dataset: G2resp_data_200324.csv
2) Data dictionary: G2resp_dictionary_200324.csv
3) R scripts: 1 x master script + 7 x sub-scripts

Please run the master script which will then source all the sub-scripts:

# Master
G2resp_00_master_script_200324.R

# Transform viral load data
G2resp_01_Viral_shedding_transformation_200324.R

# Extended Data Figure 2
G2resp_02_Weekly_number_of_respiratory_virus_infections_200324.R

# Extended Data Figure 3
G2resp_03_Respiratory_virus_shedding_200324.R

# Table 1a, Supplementary Table 1
G2resp_04_Patient_characteristics_200324.R

# Figure 1, Extended Data Figure 4, Extended Data Figure 5, Extended Data Figure 9
# Table 1b, Supplementary Table 2, Supplementary Table 3  
G2resp_05_Efficacy_of_surgical_face_masks_200324.R

# Extended Data Figure 6, Extended Data Figure 7, Extended Data Figure 8
G2resp_06_Correlation_of_respiratory_viral_shedding_between_samples_200324.R

# Supplementary Table 4, Supplementary Table 5, Supplementary Table 6 
G2resp_07_Factors_associated_with_respiratory_viral_shedding_200324.R

Funding provided by: General Research Fund, University Grants Committee, Hong Kong*
Crossref Funder Registry ID:
Award Number: 765811

Funding provided by: Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government*
Crossref Funder Registry ID:
Award Number: 13120592

Funding provided by: Theme-based Research Scheme, Research Grants Council, Hong Kong SAR Government*
Crossref Funder Registry ID:
Award Number: T11-705/14-N

Files

G2resp_data_200324.csv

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Additional details

Related works

Is cited by
10.21203/rs.3.rs-16836/v1 (DOI)