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Published September 5, 2019 | Version v1
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Data from: Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

Authors/Creators

  • 1. University of Glasgow
  • 2. University of Münster
  • 3. Goethe University Frankfurt
  • 4. University of Edinburgh
  • 5. University of Bern
  • 6. Norwegian University of Science and Technology
  • 7. University of Sydney
  • 8. Frankfurt Institute for Advanced Studies

Description

We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.

Notes

MR-Spectroscopy- and RS-high-gamma MEG data
Data associated with Figure 5 of main manuscript: correlation between high-gamma (64-90 Hz) power in occipital regions and MR-Spectroscopy measures of Glutamate/Glutamine (GLX) and GABA.
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Related works

Is cited by
10.7554/eLife.37799 (DOI)