Published October 23, 2015 | Version v1
Dataset Open

Data from: High bandwidth synaptic communication and frequency tracking in human neocortex

  • 1. VU University Amsterdam
  • 2. University of Antwerp
  • 3. VU University Medical Center
  • 4. Erasmus University Medical Center
  • 5. University of Sheffield


Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic connections were purely depressing and that they recovered three to four times more swiftly from depression than synapses in rodent neocortex. Thereby, during realistic spike trains, the temporal resolution of synaptic information exchange in human synapses substantially surpasses that in mice. Using information theory, we calculate that information transfer between human pyramidal neurons exceeds that of mouse pyramidal neurons by four to nine times, well into the beta and gamma frequency range. In addition, we found that human principal cells tracked fine temporal features, conveyed in received synaptic inputs, at a wider bandwidth than for rodents. Action potential firing probability was reliably phase-locked to input transients up to 1,000 cycles/s because of a steep onset of action potentials in human pyramidal neurons during spike trains, unlike in rodent neurons. Our data show that, in contrast to the widely held views of limited information transfer in rodent depressing synapses, fast recovering synapses of human neurons can actually transfer substantial amounts of information during spike trains. In addition, human pyramidal neurons are equipped to encode high synaptic information content. Thus, adult human cortical microcircuits relay information at a wider bandwidth than rodent microcircuits.



Files (4.2 GB)

Name Size Download all
2.4 MB Download
448.7 kB Download
24.9 kB Download
12.3 kB Download
63.5 kB Download
289.4 MB Preview Download
891.9 MB Preview Download
825.5 MB Preview Download
604.5 MB Preview Download
728.4 MB Preview Download
879.6 MB Download
374.0 kB Download
9.1 kB Download
980.5 kB Download
844.6 kB Download

Additional details

Related works