Published March 31, 2021
| Version v1
Dataset
Open
PD1 signaling network, discovery dataset 1
Authors/Creators
- 1. Harvard Chan School of Public Health
- 2. Centre for Molecular Medicine Norway
- 3. Wesleyan University
Description
Cytoscape file to reproduce the network representation of differential gene regulation in the PD1 signaling pathway in discovery dataset 1, as described in our manuscript "Regulation of PD1 signaling is associated with prognosis in glioblastoma multiforme." Node size corresponds to the number of edges connected in the graph; line-width of edges corresponds to their signi cance in di erential regulation. Gene targeting scores (or "degrees") are shown with a circle surrounding the node. Red: higher expression/targeting in short-term survivors,
blue: higher expression/targeting in the long-term survivors.
Notes
This work was supported by grants from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL111759, P01HL105339, K25HL133599, R35CA220523), from the Charles A. King Trust Postdoctoral Research Fellowship Program, Sara Elizabeth O'Brien Trust, Bank of America, N.A., Co-Trustees, and from the Norwegian Research Council, Helse Sør-Øst, and University of Oslo through the Centre for Molecular Medicine Norway (NCMM).
Files
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Additional details
References
- Lopes-Ramos et al. (2021) BioRxiv, doi: https://doi.org/10.1101/2021.02.11.430786