Published March 5, 2021
| Version v1
Dataset
Open
Supplementary dataset 11 - The effects of model complexity and size on metabolic flux distribution and control. Case study in Escherichia coli.
Description
11th part of Supplementary dataset 1-15: contains populations of 50'000 control coefficients (Metabolic Control Analysis) for three models D1, D2, and D3 of different network size. These populations of control coefficients were used to study the effects of model complexity - in terms of network size - on the conclusions drawn from MCA. A metric for measuring the sensitivity of MCA control coefficients to these structural changes was proposed.
Notes
This work was supported by funding from the Ecole Polytechnique Fédérale de Lausanne (EPFL), the 2015/313 ERASysAPP RobustYeast Project funded through SystemsX.ch, the Swiss Initiative for Systems Biology evaluated by the Swiss National Science Foundation, and the Swiss National Science Foundation grant 315230_163423. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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(45.3 GB)
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Additional details
Funding
- Swiss National Science Foundation
- Computational Methods for modeling and analysis of large-scale metabolic networks 315230_163423