Published February 24, 2021 | Version v1
Dataset Open

Environmental robustness of the global yeast genetic interaction network

Description

Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered new functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.

Notes

Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DBI\0953881

Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: R01HG005853

Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: R01HG005084

Funding provided by: Canadian Institutes of Health Research
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100000024
Award Number: FDN-143264

Funding provided by: Canadian Institutes of Health Research
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100000024
Award Number: FDN-143265

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