Correlation and transcriptomic analysis revealing potential microRNA-gene interactions associated with breast cancer formation

The results showed that the strongest negative correlation was peaked at -0.595 (p-value < 0.001); the miRNA and gene interaction was found between miR- 1307 and CBX7. Then, transcriptomic validation result also supported the correlation. Furthermore, the result of miR-1307 – CBX7 pair is also identified in the previous study through literature review. It suggests that the prediction accuracy is high. This study suggests that miR-1307 plays an oncogenic role and CBX7 potentially function as a tumor suppressor gene in breast cancer development. Taken together, correlation, transcriptomic and literature review study can be a rigorous combination pipeline to predict microRNA – gene interaction