Dryad
Published December 17, 2020 | Version v1
Dataset Open

A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

Authors/Creators

  • 1. University of Lausanne

Description

The insect chemosensory repertoires of Odorant Receptors (ORs) and Gustatory Receptors (GRs) together represent one of the largest families of ligand-gated ion channels. Previous analyses have identified homologous 'Gustatory Receptor-Like (GRL)' proteins across Animalia, but the evolutionary origin of this novel class of ion channels is unknown. We describe a survey of unicellular eukaryotic genomes for GRLs, identifying several candidates in fungi, protists and algae that contain many structural features characteristic of animal GRLs. The existence of these proteins in unicellular eukaryotes, together with ab initio protein structure predictions, provide evidence for homology between GRLs and a family of uncharacterized plant proteins containing the DUF3537 domain. Together, our analyses suggest an origin of this protein superfamily in the last common eukaryotic ancestor.

Notes

Output files of trRosetta and RaptorX analyses of selected insect Odorant Receptors (ORs) and Gustatory Receptors (GRs), other animal GR-like (GRL) proteins, unicellular eukaryotic GRL candidates and plant DUF3537 proteins. For each query, the results of a Dali full PDB search with the top model are included within the corresponding subfolder.

In the trRosetta datasets, the .npz files - which containing the predicted inter-residue geometries - can be opened with NumPy.

Funding provided by: FP7 Ideas: European Research Council
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100011199
Award Number: 615094

Funding provided by: H2020 European Research Council
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100010663
Award Number: 833548

Funding provided by: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001711
Award Number: 31003A_166646

Funding provided by: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001711
Award Number: 183723

Funding provided by: Novartis Stiftung für Medizinisch-Biologische Forschung
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004784
Award Number: N/A

Funding provided by: Novartis Stiftung für Medizinisch-Biologische Forschung
Crossref Funder Registry ID:

Files

RaptorX_Dali.zip

Files (10.4 GB)

Name Size Download all
md5:62e0d47fe4ce5d896c591d2689445dc0
7.9 GB Preview Download
md5:5a44fcf5cfe63e0ae3156bc15cab3b5e
2.5 GB Preview Download

Additional details

Related works

Is cited by
10.1101/2020.08.24.264408 (DOI)
10.7554/elife.62507 (DOI)