Towards Applications of Bioentities@MOFs in Biomedicine
Authors/Creators
- 1. Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria
- 2. Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
- 3. Department of Chemistry and the Centre of Advanced Nanomaterials, University of Adelaide, South Australia 5005, Australia
Description
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as
novel biocomposites for application to drug delivery, biosensing, biospecimen preservation, and cell and
virus manipulation. The integration of biological entities into MOF matrices generates MOF biocomposites with functional characteristics that cannot be observed in the separate components, such as
enhanced chemical and thermal stability, resistance to proteases, MOF-conferred selectivity, and controlled release. In this review, we will discuss these functional properties and applications of the biocomposites obtained by the encapsulation of (i) proteins, (ii) carbohydrates, (iii) nucleic acids, and (iv) viruses
or cells in a MOF matrix. Finally, we review the post functionalization of MOF-based drug carriers with
lipids as a potential route to enhance the dispersion, stability in biological fluids, and blood circulation
time of MOF-based drug delivery systems.
Files
CCR_manuscript_file.pdf
Additional details
Related works
- Is identical to
- Journal article: 10.1016/j.ccr.2020.213651 (DOI)