The sample data for scMLnet

The input of scMLnet includes scRNA-Seq data and clustering results.

This sample data come from nine BALF samples of COVID-19 patients (GSE145926), including three patients in moderate stage and six patients in severe stage. The integration, normalization, standardization, dimensionality reduction and tSNE visualization of the expression matrix were performed using R package Seurat v3.1.2.

please refer to the following paper for more details:

Cheng J, Zhang J, Wu Z, Sun X*. Inferring microenvironmental regulation of gene expression from single-cell RNA sequencing data using scMLnet with an application to COVID-19. Briefings in Bioinformatics. 2020. Bbaa327.

Files and datails:

• data.Rdata: the expression matrix of BALF in COVID-19 patients
• barcode.txt: the annotation of cell types