MethylDetectR - A Translational Tool for Methylation-Based Health Profiling

This dataset includes reproducible code for the two applications related to the 'MethylDetectR' software. These .R files are included as 'MethylDetectR - Calculate Your Scores.R' and 'MethylDetectR.R'. An example DNAm file and Sexinfo file for upload to 'MethylDetectR - Calculate Your Scores' are included. These are 'DNAm_File_Example.rds' and 'Sexinfo_example.csv', respectively. An example output file from this application/for upload to 'MethylDetectR' is included as 'MethylDetectR - Test For Upload.csv'. 

Furthermore, a script for the user to generate their own DNAm-based estimated values for human traits is included as 'Script_For_User_To_Generate_Scores.R'. A necessary associated file as 'Predictors_Shiny_By_Groups.csv' is also present for the script to run.

Lastly, coefficients for lifestyle traits and HDL cholesterol are attached as 'Lifestyle_Biochemical_LASSO_Coefficients.xlsx'. These coefficients are separate from those included in the original McCartney and Hillary et al (2018) publication in Genome Biology. The reason for this difference is that the attached coefficients are generated from scaled DNAm data.