Published January 1, 2021 | Version v1
Journal article Open

Synthesis, spectroscopic characterization and singlet oxygen generation of 5,10,15,20-tetrakis(3,5-dimethoxyphenyl) porphyrin as a potential photosensitizer for photodynamic therapy

Authors/Creators

  • 1. Niger Delta University, Wilberforce Island, P.M.B. 071, Yenagoa, Bayelsa State, Nigeria
  • 2. College of Science, Engineering and Technology (CSET), University of South Africa (UNISA)
  • 3. University of KwaZulu-Natal, Private Bag X 54001, Durban 4000, South Africa
  • 4. Centre for Nanomaterial Science University of Johannesburg, Doornfontein, Johannesburg, 2028, South Africa

Description

Singlet oxygen is a valuable reactive oxygen species known for its effective action on the elimination of cancers and age-related eye disease such as macular degeneration. In this study, 5,10,15,20-tetrakis (3,5-dimethoxyphenyl) porphyrin was synthesized and characterized using various spectroscopic methods. The λmax for the Soret and Q bands were 417 nm and 514, 547, 589 and 646 (nm) respectively. The estimated singlet oxygen yield (φΔ) for the porphyrin was higher than some literature reports, suggesting a stronger potential of the porphyrin for the photosensitizing photodynamic treatment of cancer and other related human disorders.

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