New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
Creators
- 1. Faculty of Chemistry, University of Belgrade, Studentski trg 12–16, Belgrade, Serbia
- 2. Innovation Center of the Faculty of Chemistry, Studentski trg 12–16, Belgrade, Serbia
- 3. Innovation Center of the Faculty of Chemistry, Studentski trg 12–16, Belgrade, Serbia; The Vinča Institute of Nuclear Sciences, University of Belgrade, P. O. Box 522, 11001 Belgrade, Serbia
- 4. Institute for Oncology and Radiology of Serbia, Pasterova 14, Belgrade, Serbia
- 5. XStruct, Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Ghent, Belgium
Description
A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
Notes
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New rutheniumII bipyridil.pdf
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Additional details
Related works
- Is documented by
- 4964 (PMID)
- Is part of
- 0352-5139 (ISSN)
Funding
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology 172035
- Ministry of Education, Science and Technological Development