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Published August 3, 2020 | Version v1.1
Software Open

Residual risk of HIV-TT Version 1.1

Authors/Creators

  • 1. Vitalant Research Institute

Contributors

  • 1. Stellenbosch University
  • 2. Food and Drug Administration
  • 3. Vitalant Research Institute

Description

A tool for estimating the residual risk of HIV transfusion transmission despite screening of blood donation samples with nucleic acid testing (NAT). The central concepts underlying the approach is the "infectious window period" (IWP) and HIV incidence in the donor population -- reflecting the probability that a random donation will be in the infectious window period. The infectious window period is a function of the viral growth rate during early ramp-up viraemia, the sensitivity of the screening assay and the volume transfused. Multiplying the infectious window period by incidence yields the probability (per transfusion) of a transfusion transmission.

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eduardgrebe/residualrisk-v1.1.zip

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Additional details

Related works

Is cited by
Journal article: 10.1182/blood.2020007003 (DOI)
Is supplement to
https://github.com/eduardgrebe/residualrisk/tree/v1.1 (URL)

References

  • Busch MP, Glynn SA, Stramer SL, Strong DM, Caglioti S, Wright DJ, Pappalardo B, Kleinman SH. A new strategy for estimating risks of transfusion-transmitted viral infections based on rates of detection of recently infected donors. Transfusion. 2005;45:254–264. doi:10.1111/j.1537-2995.2004.04215.x.
  • Weusten JJAM, Van Drimmelen HAJ, Lelie PN. Mathematic modeling of the risk of HBV, HCV, and HIV transmission by window-phase donations not detected by NAT. Transfusion. 2002;42:537–548.
  • Weusten JJAM, Vermeulen M, Van Drimmelen HAJ, Lelie PN. Refinement of a viral transmission risk model for blood donations in seroconversion window phase screened by nucleic acid testing in different pool sizes and repeat test algorithms. Transfusion. 2011;51:203-215. doi:10.1111/j.1537-2995.2010.02804.x.
  • Grebe E, Facente SN, Powrie A, Gerber J, Grootboom K, Priede G, Welte A. Infection Dating Tool. Zenodo. 2018. doi:10.5281/zenodo.1488117.