TREATMENT OF DYUSHEN MUSCULAR DYSTROPHY WITH APPLICATION OF FETAL PROGENER CELL TRANSPLANTATION

Radchenko V. V., Sirman V. M., Duzhar V. M., Gozhenko A. I. TREATMENT OF DYUSHEN MUSCULAR DYSTROPHY WITH APPLICATION OF FETAL PROGENER CELL TRANSPLANTATION. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2020;2(60):71-79. ISSN 1818-9385

DOI http://dx.doi.org/10.5281/zenodo.3967618

http://aptm.org.ua

УДК 616-073+616.83

http://dx.doi.org/10.5281/zenodo.3967618

TREATMENT OF DYUSHEN MUSCULAR DYSTROPHY WITH

APPLICATION OF FETAL PROGENER CELL TRANSPLANTATION

Radchenko V. V., Sirman V. M., Duzhar V. M., Gozhenko A. I.

KRS – Medical Technologies LLC (Kiev, Ukraine)

EmProCelll Clinical Research Pvt Ltd. (Mumbai, India)

Ukrainian SRI of Transport Medicine of the Health Ministry of Ukraine (Odessa,

Ukraine)

Summary

The authors are reviewing issues arising in the process of treatment of Duchenne muscular dystrophy (DMD) – a recessive X-linked disorder. This study focused on the effectiveness of the developed DMD treatment method.

Results. The study included 35 patients with DMD aged from 5 to 19 who underwent fetal stem cell transplantation. Laboratory tests before the treatment were remarkable for significant elevation of CPK in all the patients. Many patients also had high levels of ALT, ACT and LDH. Administration of stem cells directly into the affected muscles (intramuscularly) results in higher muscle tone, muscle bulk growth stimulation, muscle power and physical capacity increase, immune boosting, improved cognitive and intellectual skills and psychoemotional state in general.

Key words: Duchenne muscular dystrophy, stem cells, fetal progenitor cells, myoblasts, multi-point intramuscular administration.