Published November 30, 2006
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Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis
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Description
Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 \% among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.
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JGenVirol.87.Pt 11.3355-3359.pdf
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Additional details
Biodiversity
- Host of
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(Rhinolophus ferrumequinum, horseshoe bat) → (G2b-CoV Rf1)(Rhinolophus macrotis, horseshoe bat) → (G2b-CoV Rm1)(Rhinolophus pearsonii, horseshoe bat) → (SARS cluster coronaviruses or group 2b coronavirus, G2b-CoVs)(Rhinolophus pusillus, horseshoe bat) → (SARS cluster coronaviruses or group 2b coronavirus, G2b-CoVs)(Rhinolophus sinicus, horseshoe bat) → (SARS cluster coronaviruses or group 2b coronavirus, G2b-CoVs)(Rhinolophus, horseshoe bat) → (SARS coronavirus-like virus)(Rhinolophus, horseshoe bat) → (SARS-like coronavirus, SL-CoV)(palm civet) → (SARS coronaviruses, SARS-CoV)