Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

This dataset contains raw qMRI data and the corresponding calculated relaxation time maps, reference data and an example MATLAB script demonstrating how to access the data, comprising study:

Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

Journal of Orthopaedic Research | DOI: https://doi.org/10.1002/jor.24780

Kajabi Abdul Wahed*(1,2), Casula Victor(1,2), Sarin Jaakko K.(3,4), Ketola Juuso H.(1), Nykänen Olli(3), te Moller Nikae C.R.(5), Mancini Irina A.D.(5), Visser Jetze(6), Brommer Harold(5), van Weeren P. René(5), Malda Jos(5,6), Töyräs Juha(3,4,7), Nieminen Miika T.(1,2,8), Nissi Mikko J.*(1,3)

1. Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2. Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland 
3. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
4. Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
5. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
6. Department of Orthopaedics, University Medical Center Utrecht, The Netherlands 
7. School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
8. Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland 

*Corresponding authors:
Mikko J. Nissi
Department of Applied Physics,
University of Eastern Finland
POB 1627,
FI-70211, Kuopio, Finland
mikko.nissi@uef.fi
+358-50-5955517

Abdul Wahed Kajabi
Research Unit of Medical Imaging, Physics and Technology,
University of Oulu
POB 50,
FI-90029, Oulu, Finland
abdul.kajabi@oulu.fi
+358-50-3037425

Keywords: cartilage, post-traumatic, osteoarthritis, quantitative MRI, relaxation times

The file "Pony_AllData.mat" contains all the data of the study. The main struct variable in the file ("all_data") contains several fields storing all the data per sample. In the following, brief descriptions for the main subfields are given:

• name: contains generic name of the sample
• qMRI_Data: contains qMRI raw data, the corresponding relaxation time maps and normalized cartilage full-thickness ROI profiles
• calcROI_Data: contains ROIs used to calculate the relaxation time maps
• analysisROI_Data: ROIs used for the analysis
• DD_prof and interpDD_prof: Original and interpolated profiles for proteoglycan content (Optical Density)
• PLM_prof and interpPLM_prof: Original and interpolated profiles for collagen fiber orientation (Polarized Light Microscopy)
• E_eq and E_dyn: Equilibrium and dynamic moduli of articular cartilage.

The example script, "Analysis_script.m" contains a short demonstration on how the data in the struct can be accessed. The script assumes that Aedes (http://aedes.uef.fi) analysis software is available for matlab.

(Abdul Wahed Kajabi, 17 Jun 2020)